By Jack F Kay
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Extra resources for Analyses for hormonal substances in food producing animals
An NOAEL cannot be established). Yen et al (1975)30 had described the eﬀects of ingested oestradiol on plasma oestradiol, oestrone and gonadotrophin concentrations in postmenopausal vi In postmenopausal women, no ovarian oestrogen synthesis occurs and the residual oestrogen production occurs predominantly in sub-cutaneous fat and is not subject to signiﬁcant feedback control; in these circumstances, ingestion of exogenous hormone leads to additive increments of exposure. 27 (Hankinson et al, 1995).
Based on cellular morphology, the report refers to the abnormal persistence of ‘‘single’’ ‘‘foetal-like’’ germ cells in the testes of treated animals, although it is not speciﬁed in which treatment groups these cells were noted. Such cells are of interest because testicular (germ cell) cancer in humans probably arises from transformed foetal germ cells that have persisted in the testis since foetal life. However, the study was unable to conﬁrm the possible foetal nature of these cells using a battery of speciﬁc markers as none of the available antibodies worked on rabbit tissues.
Further studies to determine the biological and chemical stability of such steroids in soil and water are warranted. This conclusion is also based on Schiﬀer et al. ’s conclusions. This is an appropriate conclusion to reach; clearly the conclusion stated in (ii) above cannot be supported until these stability studies are done. Little information is available on the endocrine disrupting potential of the metabolites of MGA. This is also based on Schiﬀer et al. 68 Surface water downstream from a cattle feedlot was contaminated with oestrogenic and androgenic compounds, but the identity of these could not be established.
Analyses for hormonal substances in food producing animals by Jack F Kay